Medroxyprogesterone may also increase the risk of uterine or ovarian cancer in some women. Medroxyprogesterone acetate can cause reversibly reduced bone density, but the effect has not been found to be constant and it may vary with age. Longterm treatment with estrogens and progestins such as medroxyprogesterone may. Medroxyprogesterone is a type of female hormone progestin. As a progestogenonly contraceptive an intramuscular dose of 150 mg is given every 12 or weeks. Medroxyprogesterone acetate is a synthetic, acetate derivative of the sex hormone progesterone. Medroxyprogesterone is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. New contraceptive eligibility checklists for provision of combined oral contraceptives and depomedroxyprogesterone acetate provision in communitybased programmes amanda stang, pamela schwingl and roberto rivera. Medroxyprogesterone is a synthetic derivative of progesterone administered as an acetate salt medroxyprogesterone acetate with antiestrogenic activity. Files are available under licenses specified on their description page. Toxicology of depot medroxyprogesterone acetate alexander jordan, phd division of metabolism and endocrine drug products, united states food and drug administration depoprovera depotmedroxy progesterone acetate or dmp, ad ministered either subcutaneously or intramuscularly, has undergone a thorough toxicological evaluation in a number of animal species.
The use of medroxyprogesterone acetate for the treatment. Medroxyprogesterone acetate is also given by injection as a contraceptive see under hormonal contraceptives, p. Identification of the substancepreparation and the companyundertaking material name. New contraceptive eligibility checklists for provision of. Medroxyprogesterone acetate subcutaneous injection, 104 mg0. The hormone medroxyprogesterone acetate mpa is a known, but infrequently used, treatment option. All spectrum chemical usp grade products are manufactured, package. Phase ii study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma.
Medroxyprogesterone will not prevent heart disease, breast cancer, or dementia, and may actually increase the risk of developing these conditions in postmenopausal women. Medroxyprogesterone 17acetate mpa is synthetic progestin progestagen derived from 17hydroxyprogesterone with actions similar to progesterone. Sexually inappropriate behaviour in a patient with dementia can be a problem for caregivers. Quantitative analysis of collagen fibrillar structure in canine uterus exposed to acetate of medroxyprogesterone using second harmonic generation. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind. Medroxyprogesterone is also used to decrease the risk of endometrial hyperplasia a condition that may lead to uterine cancer while taking estrogens. Medroxyprogesterone acetate, sold under the brand name depoprovera. Medroxyprogesterone acetate, micronized, usp is a synthetic variant of the steroid hormone progesterone used mainly as a contraceptive and in hormone replacement therapy. It is a longacting hormonal contraceptive that has been used to treat or study various neoplasms breast cancer and endometrial conditions. Medroxyprogesterone 17 acetate nci04 medroxyprogesterone acetate is a steroid ester. Medroxyprogesterone acetate is an odorless white to offwhite microcrystalline powder.
The overall, nonsignificant relative rate of invasive squamouscell cervical cancer in women who ever used medroxyprogesterone acetate was estimated to be 1. Treatment of alopecia x with medroxyprogesterone acetate. Little research has been done concerning treatment for this behavioural disorder. This page was last edited on 2 january 2019, at 09. Medroxyprogesterone is also used to prevent overgrowth in the lining. Qualitative and quantitative composition provera tablet contains 2. This medication is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is. Marco tronchetti provera born 1948, italian businessman. Mpa is a progestogen and a derivative of progesterone. Medroxyprogesterone acetate an overview sciencedirect. All structured data from the file and property namespaces is available under the creative commons cc0 license. Bone density, bone turnover, and hormones have been measured in individually matched casecontrol pairs of women, of whom 50 pairs were aged 1825 years and 50 pairs 3545 89 c.
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